Methyl iodide → Ethanaminium, 2-(4-((1Z)-1,2-diphenyl-1-buten-1-yl)phenoxy)-N,N,N-trimethyl-, iodide (1:1)

Participants

Reaction Steps

Tamoxifen methiodide was prepared by reacting 2.0 g of tamoxifen (Aldrich Chemical Co., St. Louis, Mo.) with methyl iodide at 0° C. for 24 hours. Ethyl acetate was then added to afford a white precipitate, which was recrystallized from methanol to yield >99% tamoxifen methiodide. Tamoxifen benzyl bromide was synthesized by reacting tamoxifen with benzyl bromide.

Provenance & Evidence