反应详情

5.2 g of (2S,3R)-5-oxotetrahydrofuran-2,3-dicarboxylic acid in 88 ml of acetone was stirred with 6.5 g of 1,1'-dicyclohexylcarbodiimide at room temperature for 2 hours. 3.26 ml of benzyl alcohol was added, and the reaction solution was stirred at the same temperature for 12 hours. The insolubles were filtered off, the filtrate was concentrated in vacuo. The residue was purified by silica gel column chromatography [hexane/ethyl acetate=4/1→chloroform/methanol=50/1] to give 7.93 g of the title compound as a yellow solid.

1. filtrationThe insolubles were filtered off
2. concentrationthe filtrate was concentrated in vacuo
3. customThe residue was purified by silica gel column chromatography [hexane/ethyl acetate=4/1→chloroform/methanol=50/1]