HCID 18705564, compound → N-[1,2-Dihydro-1-[1-hydroxy-2-(hydroxymethyl)-4-oxo-3-azetidinyl]-2-oxo-4-pyrimidinyl]benzamide

Participants

Reaction Steps

1-N-Benzyloxy-3-(N-benzoylcytosin-1-yl)-4-benzyloxymethyl-2-azetidinone (10 mmole) is taken up in methanol (50 ml) and hydrogenated using Raney nickel (5 g) and hydrogen at a pressure of 40 psi for 6 hours. The reaction mixture is filtered, the catalyst washed with methanol (20 ml) and the combined fractions are concentrated to afford the product as a solid.

Provenance & Evidence