Sodium Bicarbonate → HCID 57756378, compound

Participants

Reaction Conditions

Reaction Steps

4-(2-Iodo-6-methyl-pyridin-3-yloxy)-6,7-dimethoxyquinoline (compound 116) (84 mg), 2-methoxyphenylboronic acid (152 mg), and tetrakistriphenylphosphine palladium (12 mg) were disssolved in toluene (1 ml) to prepare a solution. A saturated aqueous sodium hydrogencarbonate solution (1 ml) was added to the solution, and the mixture was stirred at 80° C. for 3 hr. The reaction solution was filtered, the solvent was then removed by distillation under the reduced pressure, and the residue was purified by column chromatography using methanol-chloroform to give the title compound (23 mg, yield 29%).

Provenance & Evidence