Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 2287705생성일: 2026년 10월 25일
2-(Trifluoromethyl)aniline → 4-N-[2-(trifluoromethyl)phenyl]pyrido[4,3-d]pyrimidine-4,7-diamine
https://huagongshe.com/reaction/2287705
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 2-(Trifluoromethyl)aniline | HCID 6922 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | 7-Amino-4-methylthiopyrido[4,3-d]pyrimidine | HCID 10442562 | — |
| 반응물 | Alpha,alpha,alpha-trifluoro-O-toluidine hydrochloride | HCID 22736790 | — |
| 용매 | Chloroform methanol | HCID 21584188 | — |
| 생성물 | 4-N-[2-(trifluoromethyl)phenyl]pyrido[4,3-d]pyrimidine-4,7-diamine | HCID 5328057 | 41% |
반응 단계
A mixture of 7-amino-4-methylthiopyrido[4,3-d]pyrimidine (300 mg, 1.56 mmol), 2-aminobenzotrifluoride hydrochloride (1.00 g, 5.06 mmol) and 2-aminobenzotrifluoride (2.00 g, 12.4 mmol) is stirred at 160° C. for 10 min. The resulting product is neutralized with excess NaHCO3, dissolved in MeOH/CHCl3, dried onto silica gel and chromatographed over silica gel (6-7% MeOH/CH2Cl2) to give 7-amino-4-(2-trifluoromethylanilino)pyrido[4,3-d]pyrimidine (194 mg, 41%) as a cream solid, mp (MeOH/CHCl3 /light petroleum) 126-130° C. (dec.). 1H NMR (DMSO) δ 10.60 (1H, brs), 9.17 (1H, brs), 8.13 (1H, brs), 7.76, 7.69 (1H, 1H, m, m), 7.45 (2H, m), 6.66 (2H, brs), 6.36 (1H, s).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06084095 |
|---|
| 출처 데이터셋 | uspto-grants-2000_07 |
|---|
| ORD ID | ord-9fb8c8cb8f79493599435b58936c2691 |
|---|
| 출처 메모 | uspto-grants-2000_07 |
|---|
