Mafenide → HCID 18705809, compound

Participants

Reaction Steps

Using procedure 49, 2-(dipropylamino)-2,3-dihydro-1H-indene-5,6-dicarboxylate (92, 0.35 g, 1.0 mmol) was treated with p-aminomethylbenzenesulfonamide (0.31 g, 1.4 mmol). Purification using silica gel, eluting with 4:1 CH2Cl2 /acetone, afforded a solid that recrystallized from CH2Cl2 /Et2O/hexane to give 109 as a white solid (m.p. 190-194° C.).

Provenance & Evidence