Hydrochloric Acid → HCID 18705912, compound

Participants

Reaction Steps

Using procedure 47, 6-(Dipropylamino)-6,7-dihydro-2-(phenylmethyl)cyclopent[f]isoindole-1,3(2H,5H)-dione (124, 0.41 g, 1.0 mmol) was reduced with Zinc dust (0.65 g, 10.0 mmol) in glacial HOAc (20 mL). Purification on silica gel, eluting with 3:1 hexane/acetone gave an oil that was converted to an HCl salt and recrystallized from EtOAc/MeOH to give 125 as a white solid (m.p. 235-236° C.).

Provenance & Evidence