Hydrazinium chloride → HCID 18705826, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-(dipropylamino)-2,3-dihydro-1H-indene-5,6-dicarboxylate (92, 0.17 g, 0.5 mmol) and hydrazine hydrochloride (0.05 g, 0.7 mmol) in glacial HOAc (10 mL) was refluxed at 125° C. for 4 h. The reaction was cooled, concentrated, and converted to an HCl salt. The resulting solid was recrystallized from EtOAc/MeOH to give a white solid. This white solid was further purified via reverse phase chromatography eluting with H2O/MeOH (95:5). The resulting product was converted to an HCl salt and recrystallized from hot MeOH to give 134 as a white solid (m.p.>300° C.).

Provenance & Evidence