Pyridine → HCID 10559138, compound

HRID 2287885Notes

Reaction equation

HRID 2287885 reaction equation
[C:1]([O:5][C:6]([CH3:9])([CH3:8])[CH3:7])(=[O:4])[NH:2][NH2:3].N1C=CC=CC=1.[C:16](OC(=O)C)(=[O:18])[CH3:17]>C(Cl)Cl>[C:6]([O:5][C:1]([NH:2][NH:3][C:16](=[O:18])[CH3:17])=[O:4])([CH3:9])([CH3:8])[CH3:7]

Participants

5

Reactant 3

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 70091tert-Butyl carbazate

Product 1

HCID 10559138HCID 10559138, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

To a solution of tert-butyl carbazate (1.0 g, 7.6 mmol) and pyridine (3.1 ml) in methylene chloride (5 ml) was slowly added acetic acid anhydride (1.5 ml) and the mixture was stirred overnight. The mixture was added to methylene chloride (50 ml) and washed with water (2×10 ml) and brine (10 ml) and dried (MgSO4), filtered and concentrated in vacuo to give 0.95 g of N'-acetylhydrazinecarboxylic acid tert-butyl ester as a yellow oil.

Workup

  1. washwashed with water (2×10 ml) and brine (10 ml)
  2. dry with materialdried (MgSO4)
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-151b2ab8b9534f4c8aa5a27526f445b5
Source dataset
uspto-grants-2000_07
Patent number
US06083908

Reaction notes

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