Trifluoroacetic acid → HCID 53992856, compound

Participants

Reaction Steps

N-[(1R)-2-(N'-Acetylhydrazino)-1-benzyl-2-oxoethyl]-N-methylcarbamic acid tert-butyl ester (0.81 g, 2.42 mmol) was dissolved in methylene chloride (5 ml) and trifluoroacetic acid (5 ml) was added and the mixture was stirred for 30 min at room temperature. The mixture was concentrated in vacuo and stripped three times with methylene chloride and the remaining oil was chromatographed on silica (40 g) with methylene chloride:(methanol/ammonia) (9:1) to give 0.41 g of acetic acid N'-((2R)-2-(methylamino)-3-phenylpropionyl)hydrazide as an amorphous powder.

Provenance & Evidence