HOAt → Diisopropylethylamine

Participants

Reaction Steps

Then (2E)-5-(tert-butyloxycarbonylamino)-5-methylhex-2-enoic acid (0.12 g, 0.48 mmol) was dissolved in methylene chloride (5 ml) and a mixture of 1-hydroxy-7-azabenzotriazole (0.065 g, 0.48 mmol) and 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride (0.092 g, 0.48 mmol) was added and stirred for 30 min. Then a mixture of the obtained crude product (0.18 g, 0.40 mmol) and diisopropylethylamine (0.09 ml, 0.53 mmol) was added and the mixture was stirred overnight.

Provenance & Evidence