Ammonia → 5,6-Dimethyl-2-(4,5-dimethylthiazol-2-yl)pyridin-3-ol

Participants

Reaction Conditions

Reaction Steps

(4,5-Dimethylfuran-2-yl)-(4,5-dimethylthiazol-2-yl)methanone (910 mg), methanol (7 ml), and 8 ml of a 28% aqueous ammonia solution were placed in a sealed tube, and the mixture was stirred at 160° C. overnight. The reaction solution was cooled to room temperature, the solvent was then removed by distillation under the reduced pressure, and the residue was purified by column chromatography using hexane-ethyl acetate to give 5,6-dimethyl-2-(4,5-dimethylthiazol-2-yl)pyridin-3-ol (782 mg, yield 86%).

Provenance & Evidence