Hydrochloric Acid → HCID 131721864, compound

Participants

Reaction Steps

A solution of N-[[4-[(3-methylphenyl)thio]phenyl]sulfonyl]-N-[2-(4-morpholinyl)ethyl]-D-valine, 1,1-dimethylethyl ester, from Example 1d (5.21 g, 9.08 mmol) in 12 M HCl (30 mL) and H2O (30 mL) was stirred at room temperature for 30 minutes and then heated to reflux for 25 minutes. Concentration in vacuo afforded N-[[4-[(3-methylphenyl)thio]phenyl]sulfonyl]-N-[2-(4-morpholinyl)ethyl]-D-valine, monohydrochloride, as a white solid (5.30 g). MS MH+ calc'd for C24H33N2O5S2 : 494, found: 494. HRMS calc'd for C24H33N2O5S2 : 493.1831; found: 493.1833.

Provenance & Evidence