Hydrochloric Acid → HCID 23000820, compound

Participants

Reaction Steps

In a mixed solvent of 15 ml of acetic acid and 10 ml of concentrated hydrochloric acid, 0.44 g (1.1 mmol) of (E)-1-(α-cyclopropylcarbonyl-2-fluorobenzyl)-3-ethoxycarbonylmethylidene-4-mercaptopiperidine were dissolved and the resulting solution was allowed to stand for 12 days at room temperature in a dark place. The reaction mixture was concentrated to dryness, followed by crystallization from ethyl ether. The crystals collected by filtration were purified by chromatography on a silica gel column (eluting solvent: chloroform/methanol=30/1), whereby 0.12 g (yield 27%) of the title compound were obtained as light yellowish white crystals.

Provenance & Evidence