Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrogen Peroxide | HCID 784 | — |
| Reactant | 5-Amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-(ethylthio)-1H-pyrazole-3-carbonitrile | HCID 11111714 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | Ethiprole | HCID 9930667 | 79.4% |
Reaction Steps
To a solution of 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-ethylthiopyrazole (22.25 g) in methanol was added a solution of sulfuiric acid (1.5 g) in isopropanol. Hydrogen peroxide (6.95 g of 30% aqueous solution) was added and the temperature raised to 60° C. After two hours, the reaction was filtered and the solid washed with methanol. The filtrate was washed (water), dried and recrystallized (methanol) to give 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-ethylsulfinylpyrazole (18.4 g), m.p. 173-174° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06087387 |
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| Source dataset | uspto-grants-2000_07 |
|---|
| ORD ID | ord-dab45b589ab94eb6b55c94df9155d2cc |
|---|
| Source note | uspto-grants-2000_07 |
|---|
