Water → HCID 56615802, compound

HRID 2288071Notes

Reaction equation

HRID 2288071 reaction equation
[C:1]1([CH:7]([O:14][C:15]([C:17]23[C:28]4([CH:30]=[O:31])[CH2:29][CH:20]([C:21]2([CH2:33][O:34][C:35]25[CH:47]([OH:48])[CH:41]6[CH:42]([O:43]C(=O)C)[CH:37]([CH:38]([O:40]6)[O:39]2)[O:36]5)[CH2:22][CH:23]2[CH:27]4[CH2:26][CH2:25][CH:24]2[CH3:32])[CH:19]=[C:18]3[CH:49]([CH3:51])[CH3:50])=[O:16])[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+].O>CO>[C:1]1([CH:7]([O:14][C:15]([C:17]23[C:28]4([CH:30]=[O:31])[CH2:29][CH:20]([C:21]2([CH2:33][O:34][C:35]25[CH:47]([OH:48])[CH:41]6[CH:42]([OH:43])[CH:37]([CH:38]([O:40]6)[O:39]2)[O:36]5)[CH2:22][CH:23]2[CH:27]4[CH2:26][CH2:25][CH:24]2[CH3:32])[CH:19]=[C:18]3[CH:49]([CH3:51])[CH3:50])=[O:16])[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 56621158HCID 56621158, compound

Product 1

HCID 56615802HCID 56615802, compoundYield 76%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
4 °C

Procedure

650 mg of compound (3) was dissolved in 46 ml of methanol and stirred together with 13.9 ml of 0.1 N aqueous NaOH at room temperature for 2 hours. The reaction solution mixed with 24 ml of water and stirred at 4° C. for 2 hours. The reaction solution was filtered, and the recovered precipitate was washed with water and dried to give 464 mg of compound (4) as a colorless powder.

Workup

  1. filtrationThe reaction solution was filtered
  2. washthe recovered precipitate was washed with water
  3. customdried

Sources & evidence

ORD record
ord-806f74f5eb2b47fa971ba6efd5b9832b
Source dataset
uspto-grants-2000_07
Patent number
US06087390

Reaction notes

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