1-Chloropropane → HCID 56623178, compound

Participants

Reaction Steps

50 mg of compound (6) was dissolved in 1.0 ml of dry dimethylformamide under a nitrogen atmosphere and mixed with about 4 mg of sodium hydride under cooling with ice. After 30 minutes, 56.3 μl of 1-chloropropane was added, and the reaction solution was stirred at room temperature for 3 hours. Then, the reaction solution was charged onto a silica gel column (Kieselgel 60, Merck, 1.0φ×30 cm) and eluted with n-hexane-ethyl acetate (4:1). The fraction containing the desired product was concentrated to dryness to give 21.6 mg of compound (30).

Provenance & Evidence