4-Nitrophthalimide → 4-Aminophthalimide

Participants

Reaction Steps

0.002 g of ammonium vanadate and 4 g of aluminium oxide granules containing 0.5% by weight of metallic palladium and having a particle size of 3.2 mm (as in Ex. 1) are added to a suspension consisting of 250 ml of water and 9.6 g of 4-nitrophthalimide. After displacing the air with nitrogen, the latter is replaced by hydrogen at atmospheric pressure and the suspension is stirred at room temperature for 20 hours. During this time, 100.6% of the theoretical amount of hydrogen, based on the nitrophthalimide used, is absorbed. The resulting suspension is then sieved through a sieve having a mesh width of 1 mm. The residue remaining on the sieve is washed with water and the combined aqueous phases are subsequently filtered through a paper filter. Drying at 80° C. under reduced pressure (125 mbar) gives 8.0 g (99%) of 4-aminophthalimide.

Provenance & Evidence