反应详情

温度

160 °C

(4,5-Dimethylfuran-2-yl)-(3-pyridyl)-methanone (1.8 g), methanol (30 ml), and a 28% aqueous ammonia solution (30 ml) were placed in a sealed tube and were stirred at 160° C. overnight. The reaction solution was cooled to room temperature, and the solvent was then removed by distillation under the reduced pressure. The residue was purified by column chromatography using hexane-ethyl acetate to give 5,6-dimethyl-[2,3′]-bipyridin-3-ol (1.1 g, yield 63%).

1. temperatureThe reaction solution was cooled to room temperature
2. customthe solvent was then removed by distillation under the reduced pressure
3. customThe residue was purified by column chromatography