Hydrochloric Acid → HCID 86755514, compound

Participants

Reaction Steps

To a solution of (2R)-4-[4,4-ethylenedioxy-4-(4-fluorophenyl)butyl]-1-[3,5-bis(trifluoromethyl)benzoyl]-2-(1H-indol-3-ylmethyl)piperazine (210 mg) in ethyl acetate was added 4N hydrogen chloride in ethyl acetate solution (0.5 ml) and the whole was stirred at room temperature for 23 hours. The solution was evaporated in vacuo. The residue was triturated with a mixture of ethyl acetate and diisopropyl ether to give (2R)-4-[4-(4-fluorophenyl)-4-oxobutyl]-1-[3,5-bis(trifluoromethyl)benzoyl]-2-(1H-indol-3-ylmethyl)piperazine hydrochloride (183.7 mg).

Provenance & Evidence