HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → (E)-4-morpholino-2-butenyl chloride hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | (E)-4-morpholino-2-buten-1-ol | HCID 22478312 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (E)-4-morpholino-2-butenyl chloride hydrochloride | HCID 18703519 | — |
Reaction Steps
Thionyl chloride (0.96 ml) was added dropwise to a solution of (E)-4-morpholino-2-buten-1-ol (1.03 g) in dichloromethane (10 ml) at ice-bath temperature. After 3 hours, the reaction mixture was evaporated under reduced pressure and the resulting residue was triturated with ethyl acetate to give (E)-4-morpholino-2-butenyl chloride hydrochloride (0.98 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06087357 |
| Source dataset | uspto-grants-2000_07 |
| ORD ID | ord-1cfa6e8636ae467384e4481365fc2171 |
| Source note | uspto-grants-2000_07 |