2-Methylbenzenesulfonic acid → HCID 18704226, compound

Participants

Reaction Steps

331 mg of the product obtained in Stage 4 above, 4 ml of tetrahydrofuran, 1 ml of 3,4-dihydro-2H-pyran and 16 mg of p. toluene sulphonic acid, and H2O are introduced. After 35 minutes, the reaction medium is poured into 10 ml of sodium bicarbonate+1 ml of triethylamine and extraction is carried out with 3×10 ml of chloroform, the extracts are washed with a saturated aqueous solution of sodium chloride, dried and evaporated to dryness. After chromatography on silica, eluting with methylene chloride-acetone: 9-1, 500 mg of expected product (friable white foam) is obtained.

Provenance & Evidence