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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2288346Generated: November 1, 2026

4-(Methylamino)benzonitrile → 2-[N-(4-cyanophenyl)-N-me-thylaminomethyl]benzothiazol-5-yl-carboxylic acid-N-phenyl-N-(2-ethoxycarbonylethyl)amide

https://huagongshe.com/reaction/2288346

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Methylamino)benzonitrileHCID 10964551—
Reactant2-methoxymethylbenzothiazole-5-carboxylic acid-N-phenyl-N-(2-ethoxycarbonylethyl)amideHCID 18412544—
SolventDichloromethane ethanolHCID 21584144—
Product2-[N-(4-cyanophenyl)-N-me-thylaminomethyl]benzothiazol-5-yl-carboxylic acid-N-phenyl-N-(2-ethoxycarbonylethyl)amideHCID 5445080757%

Reaction Steps

Prepared analogously to Example 9e from 4-cyano-N-methyl-aniline and 2-methoxymethyl-benzothiazole-5-carboxylic acid-N-phenyl-N-(2-ethoxycarbonylethyl)-amide. Yield: 57% of theory, Rf value: 0.46 (silica gel; dichloromethane/ethanol=19:1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06087380
Source datasetuspto-grants-2000_07
ORD IDord-e3897cec270e4ebfb082c441f7709bb8
Source noteuspto-grants-2000_07