Methylamine → 4-Methylamino-3-nitrobenzenesulfonic acid-n-methyl-n-(1-methylpiperidin-4-yl)amide

Participants

Reaction Steps

1.6 g (4.6 mMol) of 4-chloro-3-nitrobenzenesulphonic acid-N-methyl-N-(1-methyl-piperidin-4-yl)-amide was mixed with 30 ml of 40% methylamine solution and stirred in a sealed flask for four hours at room temperature. Then the mixture was diluted with about 40 ml of water, the product precipitated was suction filtered, washed with water and dried. Yield: 1.5 g (95% of theory), C14H22N4O4S (343.4) Rf value: 0.45 (silica gel; dichloromethane/ethanol=4:1)

Provenance & Evidence