反应详情

1.5 g (4.4 mMol) of 4-methylamino-3-nitrobenzenesulphonic acid-N-methyl-N-(1-methyl-piperidin-4-yl)-amide were dissolved in 100 ml methanol and catalytically hydrogenated at room temperature and under 5 bar hydrogen pressure (10% palladium on charcoal). Then the catalyst was filtered off and the filtrate was evaporated down. The resulting oily product was further reacted without any purification. Yield: 1.4 g (100% of theory), C14H24N4O2S (312.4) Rf value: 0.33 (silica gel; dichloromethane/ethanol=4:1)

1. filtrationThen the catalyst was filtered off
2. customthe filtrate was evaporated down
3. customThe resulting oily product was further reacted without any purification