HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(4-Cyanophenyl)glycine → 1-Methyl-2-[n-(4-cyanophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-n-(2-pyridyl)-n-ethoxycarbonylmethylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(4-Cyanophenyl)glycine | HCID 817965 | — |
| Reactant | 3-Amino-4-methylaminobenzoic acid-n-(2-pyridyl)-n-ethoxycarbonylmethylamide | HCID 18412538 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | 1-Methyl-2-[n-(4-cyanophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-n-(2-pyridyl)-n-ethoxycarbonylmethylamide | HCID 18412557 | 24% |
Reaction Steps
Prepared analogously to Example 25c from N-(4-cyanophenyl)-glycine and 3-amino-4-methylamino-benzoic acid-N-(2-pyridyl)-N-ethoxycarbonylmethyl-amide. Yield: 24% of theory, Rf value: 0.56 (silica gel; dichloromethane/methanol=4:1)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06087380 |
| Source dataset | uspto-grants-2000_07 |
| ORD ID | ord-6441ba3a9be844fba8a494ec6d7cf338 |
| Source note | uspto-grants-2000_07 |