HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(3-Amino-4-(methylamino)benzoyl)-N-2-pyridinyl-beta-alanine ethyl ester → 1-Methyl-2-[2-(2-cyanothiophen-5-yl)ethyl]benzimidazol-5-yl-carboxylic acid-n-(2-pyridyl)-n-(2-ethoxycarbonylethyl)amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(3-Amino-4-(methylamino)benzoyl)-N-2-pyridinyl-beta-alanine ethyl ester | HCID 11982993 | — |
| Reactant | 3-(5-Cyanothiophen-2-yl)propanoic acid | HCID 18412501 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | 1-Methyl-2-[2-(2-cyanothiophen-5-yl)ethyl]benzimidazol-5-yl-carboxylic acid-n-(2-pyridyl)-n-(2-ethoxycarbonylethyl)amide | HCID 18412405 | 18% |
Reaction Steps
Prepared analogously to Example 25c from 3-(2-cyanothiophen-5-yl)-propionic acid and 3-amino-4-methylamino-benzoic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide. Yield: 18% of theory, Rf value: 0.66 (silica gel; dichloromethane/methanol=9:1)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06087380 |
| Source dataset | uspto-grants-2000_07 |
| ORD ID | ord-535579c3a9f345cbaafbd5223ae32252 |
| Source note | uspto-grants-2000_07 |