Sodium Hydroxide → HCID 18412358, compound

HRID 2288397Notes

Reaction equation

HRID 2288397 reaction equation
Cl.[N:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]([CH2:31][CH2:32][C:33]([O:35]CC)=[O:34])[C:9]([C:11]1[CH:30]=[CH:29][C:14]2[N:15]([CH3:28])[C:16]([CH2:18][CH2:19][C:20]3[S:24][C:23]([C:25](=[NH:27])[NH2:26])=[CH:22][CH:21]=3)=[N:17][C:13]=2[CH:12]=1)=[O:10].[OH-].[Na+]>>[N:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]([CH2:31][CH2:32][C:33]([OH:35])=[O:34])[C:9]([C:11]1[CH:30]=[CH:29][C:14]2[N:15]([CH3:28])[C:16]([CH2:18][CH2:19][C:20]3[S:24][C:23]([C:25](=[NH:26])[NH2:27])=[CH:22][CH:21]=3)=[N:17][C:13]=2[CH:12]=1)=[O:10]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 184124711-Methyl-2-[2-(2-amidinothiophen-5-yl)ethyl]-benzimidazol-5-yl-carboxylicacid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)-amide-hydrochloride

Product 1

HCID 18412358HCID 18412358, compoundYield 98%

Procedure

Prepared analogously to Example 26 from 1-methyl-2-[2-(2-amidinothiophen-5-yl)ethyl]-benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)-amide-hydrochloride and sodium hydroxide solution. Yield: 98% of theory, C24H24N6O3S (476.6) ##EQU35##

Sources & evidence

ORD record
ord-c58dc86b2a9b4d38aaf205ddce182f1c
Source dataset
uspto-grants-2000_07
Patent number
US06087380

Reaction notes

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