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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2288399Generated: October 26, 2026

Sodium Hydroxide → Dabigatran

https://huagongshe.com/reaction/2288399

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium HydroxideHCID 14798—
ReactantEthyl 3-(2-(((4-carbamimidoylphenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo(d)imidazole-5-carboxamido)propanoate hydrochlorideHCID 18412337—
ProductDabigatranHCID 21621091%

Reaction Steps

Prepared analogously to Example 26 from 1-methyl-2-[N-(4-amidinophenyl)-aminomethyl]-benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)-amide-hydrochloride and sodium hydroxide solution. Yield: 91% of theory, C25H25N7O3 (471.5) ##EQU37##

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06087380
Source datasetuspto-grants-2000_07
ORD IDord-6d014f0e3ef645989ebb7901b241c61a
Source noteuspto-grants-2000_07