HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(4-Cyanophenyl)-propionic acid → 1-Methyl-2-[2-(4-cyanophenyl)-ethyl]-benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(4-Cyanophenyl)-propionic acid | HCID 9361742 | — |
| Reactant | N-(3-Amino-4-(methylamino)benzoyl)-N-2-pyridinyl-beta-alanine ethyl ester | HCID 11982993 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | 1-Methyl-2-[2-(4-cyanophenyl)-ethyl]-benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)-amide | HCID 18412335 | 22% |
Reaction Steps
Prepared analogously to Example 149a from 3-(4-cyanophenyl)-propionic acid and 3-amino-4-methylamino-benzoic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)-amide. Yield: 22% of theory, Rf value: 0.68 (silica gel; dichloromethane/methanol=19:1)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06087380 |
| Source dataset | uspto-grants-2000_07 |
| ORD ID | ord-c3f3737a18dd43438982d2f8a09ed5bc |
| Source note | uspto-grants-2000_07 |