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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2288413Generated: October 29, 2026

Sodium Hydroxide → 1-Methyl-2-[N-(4-amidinophenyl)-N-methlaminomethyl]benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-hydroxycarbonylethyl)amide

https://huagongshe.com/reaction/2288413

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium HydroxideHCID 14798—
Reactant1-methyl-2-[N-(4-amidinophenyl)-N-methylaminomethyl]benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide hydrochlorideHCID 18412298—
Product1-Methyl-2-[N-(4-amidinophenyl)-N-methlaminomethyl]benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-hydroxycarbonylethyl)amideHCID 1841239366%

Reaction Steps

Prepared analogously to Example 26 from 1-methyl-2-[N-(4-amidinophenyl)-N-methyl-aminomethyl]-benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)-amide-hydrochloride and sodium hydroxide solution. Yield: 66% of theory, C26H27N7O3 (485.6) ##EQU46##

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06087380
Source datasetuspto-grants-2000_07
ORD IDord-047cbd10601d484e9b529aab55444c77
Source noteuspto-grants-2000_07