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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2288414Generated: November 2, 2026

Hydrochloric Acid → 1-methyl-2-[2-(4-amidinophenyl)ethyl]benzimidazol-5-yl-carboxylic acid-N-cyclopentyl-N-(2-ethoxycarbonylethyl)amide hydrochloride

https://huagongshe.com/reaction/2288414

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantAmmonium CarbonateHCID 517111—
ReactantHCID 18412582HCID 18412582—
SolventEthanolHCID 702—
Product1-methyl-2-[2-(4-amidinophenyl)ethyl]benzimidazol-5-yl-carboxylic acid-N-cyclopentyl-N-(2-ethoxycarbonylethyl)amide hydrochlorideHCID 1841270965%

Reaction Steps

Prepared analogously to Example 25d from 1-methyl-2-[2-(4-cyanophenyl)ethyl]-benzimidazol-5-yl-carboxylic acid-N-cyclopentyl-N-(2-ethoxycarbonylethyl)-amide and ethanolic hydrochloric acid, ethanol and ammonium carbonate. Yield: 65% of theory, C28H35N5O3 (489.6) EKA mass spectrum: (M+H)+ =490

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06087380
Source datasetuspto-grants-2000_07
ORD IDord-f5d712be597440eea4cb557af9ff70c8
Source noteuspto-grants-2000_07