HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbonochloridic acid, octyl ester → methyl 3-(N-[1-methyl-2-[[4-(N-octoxycarbonylcarbamimidoyl)anilino]methyl]benzimidazole-5-carbonyl]anilino)propanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbonochloridic acid, octyl ester | HCID 81956 | — |
| Reactant | 1-Methyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(2-methoxycarbonylethyl)amide Hydrochloride | HCID 18412701 | — |
| Solvent | Dichloromethane ethanol | HCID 21584144 | — |
| Product | methyl 3-(N-[1-methyl-2-[[4-(N-octoxycarbonylcarbamimidoyl)anilino]methyl]benzimidazole-5-carbonyl]anilino)propanoate | HCID 140409609 | 41% |
Reaction Steps
Prepared analogously to Example 90 from 1-methyl-2-[N-(4-amidinophenyl)-aminomethyl]-benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(2-methoxycarbonylethyl)-amide-hydrochloride and n-octyl chloroformate. Yield: 41% of theory, C36H44N6O5 (640.8) Rf value: 0.43 (silica gel; dichloromethane/ethanol=19:1) ##EQU66##
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06087380 |
| Source dataset | uspto-grants-2000_07 |
| ORD ID | ord-c964fdabb44647f89261825a2385d0ff |
| Source note | uspto-grants-2000_07 |