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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2288440Generated: November 1, 2026

Carbonochloridic acid, heptyl ester → methyl 3-(N-[2-[[4-(N-heptoxycarbonylcarbamimidoyl)anilino]methyl]-1-methylbenzimidazole-5-carbonyl]anilino)propanoate

https://huagongshe.com/reaction/2288440

Reaction equation

Participants

RoleNameHCIDCharge
ReactantCarbonochloridic acid, heptyl esterHCID 118547—
Reactant1-Methyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(2-methoxycarbonylethyl)amide HydrochlorideHCID 18412701—
SolventDichloromethane ethanolHCID 21584144—
Productmethyl 3-(N-[2-[[4-(N-heptoxycarbonylcarbamimidoyl)anilino]methyl]-1-methylbenzimidazole-5-carbonyl]anilino)propanoateHCID 14043559543%

Reaction Steps

Prepared analogously to Example 90 from 1-methyl-2-[N-(4-amidinophenyl)-aminomethyl]-benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(2-methoxycarbonylethyl)-amide-hydrochloride and n-heptyl chloroformate. Yield: 43% of theory, C35H42N6O5 (626.8) Rf value: 0.40 (silica gel; dichloromethane/ethanol=19:1) ##EQU68##

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06087380
Source datasetuspto-grants-2000_07
ORD IDord-3ffa6454511d42f3b36c68b04d1b27c8
Source noteuspto-grants-2000_07