HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hexyl chloroformate → propyl 3-(N-[2-[[4-(N-hexoxycarbonylcarbamimidoyl)anilino]methyl]-1-methylbenzimidazole-5-carbonyl]anilino)propanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hexyl chloroformate | HCID 22466 | — |
| Reactant | 1-methyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(2-n-propyloxycarbonylethyl)amide hydrochloride | HCID 18412549 | — |
| Solvent | Dichloromethane ethanol | HCID 21584144 | — |
| Product | propyl 3-(N-[2-[[4-(N-hexoxycarbonylcarbamimidoyl)anilino]methyl]-1-methylbenzimidazole-5-carbonyl]anilino)propanoate | HCID 140409621 | 31% |
Reaction Steps
Prepared analogously to Example 90 from 1-methyl-2-[N-(4-amidinophenyl)-aminomethyl]-benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(2-n-propyloxycarbonylethyl)-amide-hydrochloride and n-hexyl chloroformate. Yield: 31% of theory, C36H44N6O5 (640.8) Rf value: 0.42 (silica gel; dichloromethane/ethanol=19:1) ##EQU69##
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06087380 |
| Source dataset | uspto-grants-2000_07 |
| ORD ID | ord-cc951c99c6bc4d0a943fc78a629312ab |
| Source note | uspto-grants-2000_07 |