HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hexyl chloroformate → Dabigatran Etexilate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hexyl chloroformate | HCID 22466 | — |
| Reactant | Ethyl 3-(2-(((4-carbamimidoylphenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo(d)imidazole-5-carboxamido)propanoate hydrochloride | HCID 18412337 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | Dabigatran Etexilate | HCID 135565674 | 51% |
Reaction Steps
Prepared analogously to Example 90 from 1-methyl-2-[N-(4-amidinophenyl)-aminomethyl]-benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)-amide-hydrochloride and n-hexyl chloroformate. Yield: 51% of theory, C34H41N7O5 (627.8) Rf value: 0.53 (silica gel; dichloromethane/methanol=9:1) ##EQU82##
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06087380 |
| Source dataset | uspto-grants-2000_07 |
| ORD ID | ord-f63343c74daf4c10902d817a857431b8 |
| Source note | uspto-grants-2000_07 |