Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2288457Generated: October 25, 2026

Carbonochloridic acid, octyl ester → O-Octyl Dabigatran Ethyl Ester

https://huagongshe.com/reaction/2288457

Reaction equation

Participants

RoleNameHCIDCharge
ReactantCarbonochloridic acid, octyl esterHCID 81956—
ReactantEthyl 3-(2-(((4-carbamimidoylphenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo(d)imidazole-5-carboxamido)propanoate hydrochlorideHCID 18412337—
SolventDichloromethane methanolHCID 21226129—
ProductO-Octyl Dabigatran Ethyl EsterHCID 14040959557%

Reaction Steps

Prepared analogously to Example 90 from 1-methyl-2-[N-(4-amidinophenyl)-aminomethyl]-benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)-amide-hydrochloride and n-octyl chloroformate. Yield: 57% of theory, C36H45N7O5 (655.8) Rf value: 0.46 (silica gel; dichloromethane/methanol =9:1 ##EQU83##

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06087380
Source datasetuspto-grants-2000_07
ORD IDord-f7749154b0b64cfa88c9a6e2a3297bb0
Source noteuspto-grants-2000_07