HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbonochloridic acid, octyl ester → ethyl 3-[[1-methyl-2-[[4-(N-octoxycarbonylcarbamimidoyl)anilino]methyl]benzimidazole-5-carbonyl]-pyridin-3-ylamino]propanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbonochloridic acid, octyl ester | HCID 81956 | — |
| Reactant | 1-methyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-(3-pyridyl)-N-(2-ethoxycarbonylethyl)amide hydrochloride | HCID 18412473 | — |
| Solvent | Dichloromethane ethanol | HCID 21584144 | — |
| Product | ethyl 3-[[1-methyl-2-[[4-(N-octoxycarbonylcarbamimidoyl)anilino]methyl]benzimidazole-5-carbonyl]-pyridin-3-ylamino]propanoate | HCID 140443503 | 35% |
Reaction Steps
Prepared analogously to Example 90 from 1-methyl-2-[N-(4-amidinophenyl)-aminomethyl]-benzimidazol-5-yl-carboxylic acid-N-(3-pyridyl)-N-(2-ethoxycarbonylethyl)-amide-hydrochloride and n-octyl chloroformate. Yield: 35% of theory, C36H45N7O5 (655.8) Rf value: 0.28 (silica gel; dichloromethane/ethanol=19:1) ##EQU87##
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06087380 |
| Source dataset | uspto-grants-2000_07 |
| ORD ID | ord-207416d082d0401caf26d9fe40ffa6a8 |
| Source note | uspto-grants-2000_07 |