HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hexyl chloroformate → ethyl 3-[[2-[[4-(N-hexoxycarbonylcarbamimidoyl)-N-methylanilino]methyl]-1-methylbenzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hexyl chloroformate | HCID 22466 | — |
| Reactant | 1-methyl-2-[N-(4-amidinophenyl)-N-methylaminomethyl]benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide hydrochloride | HCID 18412298 | — |
| Solvent | Dichloromethane ethanol | HCID 21584144 | — |
| Product | ethyl 3-[[2-[[4-(N-hexoxycarbonylcarbamimidoyl)-N-methylanilino]methyl]-1-methylbenzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoate | HCID 140409610 | 58% |
Reaction Steps
Prepared analogously to Example 90 from 1-methyl-2-[N-(4-amidinophenyl)-N-methyl-aminomethyl]-benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)-amide-hydrochloride and n-hexyl chloroformate. Yield: 58% of theory, C35H43N7O5 (641.2) Rf value: 0.42 (silica gel; dichloromethane/ethanol=19:1) ##EQU88##
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06087380 |
| Source dataset | uspto-grants-2000_07 |
| ORD ID | ord-91a89e5b48aa447ab486bdff029f9b56 |
| Source note | uspto-grants-2000_07 |