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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2288486Generated: October 30, 2026

Sodium Hydroxide → 1-Cyclopropyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(2-hydroxycarbonylethyl)amide

https://huagongshe.com/reaction/2288486

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium HydroxideHCID 14798—
Reactant1-Cyclopropyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(2-ethoxycarbonylethyl)amide HydrochlorideHCID 18412529—
Product1-Cyclopropyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(2-hydroxycarbonylethyl)amideHCID 1841239864%

Reaction Steps

Prepared analogously to Example 26 from 1-cyclopropyl-2-[N-(4-amidinophenyl)-aminomethyl]-benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(2-ethoxycarbonylethyl)-amide-hydrochloride and sodium hydroxide solution. Yield: 64% of theory, C28H28N6O3 (496.6) ##EQU99##

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06087380
Source datasetuspto-grants-2000_07
ORD IDord-db88a686c9c349f79dd98439ffb9b1ea
Source noteuspto-grants-2000_07