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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2288489Generated: October 27, 2026

Carbonochloridic acid, octyl ester → ethyl 3-(N-[1-methyl-2-[[4-(N-octoxycarbonylcarbamimidoyl)anilino]methyl]benzimidazole-5-carbonyl]anilino)propanoate

https://huagongshe.com/reaction/2288489

Reaction equation

Participants

RoleNameHCIDCharge
ReactantCarbonochloridic acid, octyl esterHCID 81956—
Reactant1-Methyl-2-[N-(4-amidinophenyl)-aminomethyl]-benzimidazol-5-yl-carboxylicacid-N-phenyl-N-(2-ethoxycarbonylethyl)-amide-hydrochlorideHCID 18412553—
SolventDichloromethane ethanolHCID 21584144—
Productethyl 3-(N-[1-methyl-2-[[4-(N-octoxycarbonylcarbamimidoyl)anilino]methyl]benzimidazole-5-carbonyl]anilino)propanoateHCID 14040959334%

Reaction Steps

Prepared analogously to Example 90 from 1-methyl-2-[N-(4-amidinophenyl)-aminomethyl]-benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(2-ethoxycarbonylethyl)-amide-hydrochloride and n-octyl chloroformate. Yield: 34% of theory, C37H46N6O5 (654.8) Rf value: 0.15 (silica gel; dichloromethane/ethanol=19:1) ##EQU102##

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06087380
Source datasetuspto-grants-2000_07
ORD IDord-db4db05f76e741a48bfc5b0b1db44243
Source noteuspto-grants-2000_07