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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2288490Generated: October 30, 2026

Hydrochloric Acid → 1-Methyl-2-[N-(4-amidino-2-ethylphenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(2-ethoxycarbonylethyl)amide hydrochloride

https://huagongshe.com/reaction/2288490

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantAmmonium CarbonateHCID 517111—
ReactantHCID 18412545HCID 18412545—
SolventEthanolHCID 702—
Product1-Methyl-2-[N-(4-amidino-2-ethylphenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(2-ethoxycarbonylethyl)amide hydrochlorideHCID 1841264361%

Reaction Steps

Prepared analogously to Example 25d from 1-methyl-2-[N-(4-cyano-2-ethyl-phenyl)-aminomethyl]-benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(2-ethoxycarbonylethyl)-amide, ethanolic hydrochloric acid, ethanol and ammonium carbonate. Yield: 61% of theory C30H34N6O3 (526.6) ##EQU103##

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06087380
Source datasetuspto-grants-2000_07
ORD IDord-72771388d9f042bbb0fd43c4ce7e4339
Source noteuspto-grants-2000_07