Sodium Hydroxide → HCID 18412456, compound

HRID 2288498Notes

Reaction equation

HRID 2288498 reaction equation
Cl.[C:2]1([N:8]([CH2:33][CH2:34][C:35]([O:37]CC)=[O:36])[S:9]([C:12]2[CH:32]=[CH:31][C:15]3[N:16]([CH3:30])[C:17]([CH2:19][NH:20][C:21]4[CH:26]=[CH:25][C:24]([C:27](=[NH:29])[NH2:28])=[CH:23][CH:22]=4)=[N:18][C:14]=3[CH:13]=2)(=[O:11])=[O:10])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>>[C:2]1([N:8]([CH2:33][CH2:34][C:35]([OH:37])=[O:36])[S:9]([C:12]2[CH:32]=[CH:31][C:15]3[N:16]([CH3:30])[C:17]([CH2:19][NH:20][C:21]4[CH:26]=[CH:25][C:24]([C:27](=[NH:28])[NH2:29])=[CH:23][CH:22]=4)=[N:18][C:14]=3[CH:13]=2)(=[O:11])=[O:10])[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 18412309HCID 18412309, compound

Product 1

HCID 18412456HCID 18412456, compoundYield 24%

Procedure

Prepared analogously to Example 26 from 1-methyl-2-[N-(4-amidinophenyl)-aminomethyl]-benzimidazol-5-yl-sulphonic acid-N-phenyl-N-(2-ethoxycarbonylethyl)-amide-hydrochloride and sodium hydroxide solution. Yield: 24% of theory, Rf value: 0.55 (Reverse-Phase RP-18 silica gel; methanol/5% saline solution=3:2) C25H26N6O4S (506.6) ##EQU112##

Sources & evidence

ORD record
ord-f84dbb521c57441ca93d0b714b607979
Source dataset
uspto-grants-2000_07
Patent number
US06087380

Reaction notes

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