Ammonia → Methyl 2-[2-(4-cyanophenyl)-ethyl]-quinazoline-7-carboxylate

Participants

Reaction Steps

0.6 g (1.8 mmol) of ethyl 3-[3-(4-cyanophenyl)-propionylamino]-4-formyl-benzoate and 10 ml of methanolic ammonia solution were agitated in a pressure vessel for 36 hours. Then the solvent was distilled off, the residue was chromatographed on silica gel and eluted with methylene chloride containing 0 to 1% methanol. Yield: 0.35 g (62% of theory), Rf value: 0.38 (silica gel, ethyl acetate/cyclohexane=1:1)

Provenance & Evidence