Sodium Hydroxide → HCID 18412535, compound

HRID 2288505Notes

Reaction equation

HRID 2288505 reaction equation
Cl.[CH3:2][N:3]1[CH:7]=[C:6]([N:8]([CH2:33][CH2:34][C:35]([O:37]CC)=[O:36])[S:9]([C:12]2[CH:32]=[CH:31][C:15]3[N:16]([CH3:30])[C:17]([CH2:19][NH:20][C:21]4[CH:26]=[CH:25][C:24]([C:27](=[NH:29])[NH2:28])=[CH:23][CH:22]=4)=[N:18][C:14]=3[CH:13]=2)(=[O:11])=[O:10])[CH:5]=[N:4]1.[OH-].[Na+]>CO>[CH3:2][N:3]1[CH:7]=[C:6]([N:8]([CH2:33][CH2:34][C:35]([OH:37])=[O:36])[S:9]([C:12]2[CH:32]=[CH:31][C:15]3[N:16]([CH3:30])[C:17]([CH2:19][NH:20][C:21]4[CH:22]=[CH:23][C:24]([C:27](=[NH:28])[NH2:29])=[CH:25][CH:26]=4)=[N:18][C:14]=3[CH:13]=2)(=[O:11])=[O:10])[CH:5]=[N:4]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 18412489HCID 18412489, compound

Product 1

HCID 18412535HCID 18412535, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Prepared analogously to Example 26 from 1-methyl-2-[N-(4-amidinophenyl)-aminomethyl]-benzimidazol-5-yl-sulphonic acid-N-(1-methylpyrazol-4-yl)-N-(2-ethoxycarbonylethyl)-amide-hydrochloride and sodium hydroxide solution. Yield: 95% of theory, C23H26N8O4S (510.6) Rf value: 0.53 (Reversed Phase silica gel RP-18, methanol+5% saline solution) ##EQU113##

Sources & evidence

ORD record
ord-945beaf4388d496a9610d721a3dcfa61
Source dataset
uspto-grants-2000_07
Patent number
US06087380

Reaction notes

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