HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 212321-78-3
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Dabigatran Etexilate | HCID 135565674 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | 212321-78-3 | HCID 135565549 | 97% |
Reaction Steps
Prepared analogously to Example 26 from 1-methyl-2-[N-[4-(N-n-hexyloxycarbonylamidino)phenyl]-aminomethyl]-benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)-amide and sodium hydroxide solution. Yield: 97% of theory, C32H37N7O5 (599.7) Rf value: 0.22 (silica gel; dichloromethane/methanol=9:1) ##EQU123##
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06087380 |
| Source dataset | uspto-grants-2000_07 |
| ORD ID | ord-84bee6ffc6324699b758caef51bc0d8e |
| Source note | uspto-grants-2000_07 |