Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2288528Generated: November 1, 2026

Sodium Hydroxide → 1-Methyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-(3-fluorophenyl)-N-(2-hydroxycarbonylethyl)amide

https://huagongshe.com/reaction/2288528

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium HydroxideHCID 14798—
ReactantHCID 18412435HCID 18412435—
SolventDichloromethane ethanolHCID 21584144—
Product1-Methyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-(3-fluorophenyl)-N-(2-hydroxycarbonylethyl)amideHCID 1841233897%

Reaction Steps

Prepared analogously to Example 26 from 1-methyl-2-[N-(4-amidinophenyl)-aminomethyl]-benzimidazol-5-yl-carboxylic acid-N-(3-fluorophenyl)-N-(2-ethoxycarbonylethyl)-amide-hydrochloride and sodium hydroxide solution. Yield: 97% of theory, C26H25FN6O3 (488.5) Rf value: 0.13 (silica gel; dichloromethane/ethanol=4:1) ##EQU127##

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06087380
Source datasetuspto-grants-2000_07
ORD IDord-3e60d1bbebef46719efde2ac0af65bdf
Source noteuspto-grants-2000_07