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Hydrochloric Acid → 1-Methyl-2-[-(4-amidino-2-methoxyphenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(2-ethoxycarbonylethyl)amide hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | Ammonium Carbonate | HCID 517111 | — |
| 反応物 | 1-methyl-2-[N-(4-cyano-2-methoxyphenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(2-ethoxycarbonylethyl)amide | HCID 18412657 | — |
| 溶媒 | Dichloromethane ethanol | HCID 21584144 | — |
| 生成物 | 1-Methyl-2-[-(4-amidino-2-methoxyphenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(2-ethoxycarbonylethyl)amide hydrochloride | HCID 18412296 | 89% |
反応手順
Prepared analogously to Example 25d from 1-methyl-2-[N-(4-cyano-2-methoxy-phenyl)-aminomethyl]-benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(2-ethoxycarbonylethyl)-amide and ethanolic hydrochloric acid, ethanol and ammonium carbonate. Yield: 89% of theory, C29H32N6O4 (528.6) Rf value: 0.13 (silica gel; dichloromethane/ethanol=4:1) ##EQU129##
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06087380 |
| 出典データセット | uspto-grants-2000_07 |
| ORD ID | ord-528ef0d3e680408e8d1c1c23fe4182d1 |
| 出典メモ | uspto-grants-2000_07 |