Sodium Hydroxide → HCID 135690256, compound

HRID 2288543Notes

Reaction equation

HRID 2288543 reaction equation
Cl.[N:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]([CH2:31][CH2:32][C:33]([O:35]CC)=[O:34])[C:9]([C:11]1[CH:30]=[CH:29][C:14]2[N:15]([CH3:28])[C:16]([CH2:18][NH:19][C:20]3[S:21][C:22]([C:25](=[NH:27])[NH2:26])=[CH:23][N:24]=3)=[N:17][C:13]=2[CH:12]=1)=[O:10].[OH-].[Na+]>ClCCl.CO>[N:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]([CH2:31][CH2:32][C:33]([OH:35])=[O:34])[C:9]([C:11]1[CH:30]=[CH:29][C:14]2[N:15]([CH3:28])[C:16]([CH2:18][NH:19][C:20]3[S:21][C:22]([C:25](=[NH:26])[NH2:27])=[CH:23][N:24]=3)=[N:17][C:13]=2[CH:12]=1)=[O:10]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 135690254HCID 135690254, compound

Product 1

HCID 135690256HCID 135690256, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

Prepared analogously to Example 26 from 1-methyl-2-[N-(5-amidino-thiazol-2-yl)-aminomethyl]-benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)-amide-hydrochloride and sodium hydroxide solution. Yield: % of theory, C22H22N8O3S (478.5) Rf value: (silica gel; dichloromethane/methanol=4:1)

Sources & evidence

ORD record
ord-a584c5885e6f4f4691985b0345eb65b6
Source dataset
uspto-grants-2000_07
Patent number
US06087380

Reaction notes

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