HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl chloroformate → ethyl 3-[[2-[[4-(N-ethoxycarbonylcarbamimidoyl)-2-methoxyanilino]methyl]-1-methylbenzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl chloroformate | HCID 10928 | — |
| Reactant | 1-methyl-2-[N-(4-amidino-2-methoxyphenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide hydrochloride | HCID 18412588 | — |
| Solvent | Dichloromethane ethanol | HCID 21584144 | — |
| Product | ethyl 3-[[2-[[4-(N-ethoxycarbonylcarbamimidoyl)-2-methoxyanilino]methyl]-1-methylbenzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoate | HCID 140435597 | 43% |
Reaction Steps
Prepared analogously to Example 90 from 1-methyl-2-[N-(4-amidino-2-methoxy-phenyl)-aminomethyl]-benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)-amide-hydrochloride and ethyl chloroformate. Yield: 43% of theory, C31H35N7O6 (601.7) Rf value: 0.44 (silica gel; dichloromethane/ethanol=9:1) ##EQU142##
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06087380 |
| Source dataset | uspto-grants-2000_07 |
| ORD ID | ord-efd0d140d4c243419d7ef24a0b8bf901 |
| Source note | uspto-grants-2000_07 |